Picture of Ekaterina  Dadachova

Ekaterina Dadachova Professor

Address
3D01.8 Health Sciences

Bio

As of November 1st 2016, Dr. Ekaterina (Kate) Dadachova is the Fedoruk Centre for Nuclear Innovation Chair in Radiopharmacy. She was most recently a Professor of Radiology, Microbiology and Immunology in the Albert Einstein College of Medicine at Yeshiva University, where she was also the Sylvia and Robert S. Olnick Faculty Scholar in Cancer Research. She received her PhD in Physical Chemistry from Moscow State University in 1992, and completed a postdoctoral fellowship in radiopharmaceutical chemistry at the Australian Nuclear Science and Technology Organization.

Research

Dadachova’s laboratory has pioneered the treatment of infectious diseases including fungal and bacterial infections and HIV with radiolabeled antibodies (so called radioimmunotherapy). Her other research interests are radioimmunotherapy of melanoma, cervical and pancreatic cancer as well development of melanin-based radioprotectors for cancer patients undergoing radiation therapy and for soldiers on the battlefield. She has brought with her to Canada an active research program which is  funded by the United States Department of Defense, National Institutes of  Health (NIH),  and pharmaceutical industry.

Recent Publications

Tsukrov D, McFarren A, Morgenstern A, Bruchertseifer F,  Dolce E, Gorny MK, Zolla-Pazner S, Berman JW, Schoenbaum E,  Zingman BS, Casadevall A and Dadachova E. Combination of anti-retroviral drugs and radioimmunotherapy specifically kills infected cells from HIV infected individuals. Front. Med.  (Lausanne) Sep 26;3:41 (2016).

DS Geller, J Morris, E Revskaya, M Kahn, W Zhang, S Piperdi, A Park, P Koirala, H Guzik, C Hall, B Hoang, R Yang, M Roth, J Gill, R Gorlick, E Dadachova Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R). Nucl. Med. Biol. 43(12):812-817 (2016).

A. Norain and E. Dadachova Targeted Radionuclide Therapy of Melanoma. Seminars Nucl. Med. 46(3):250-9 (2016).

Shuryak I, Dadachova E. Quantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other Stressors. PLoS One 25;11(1):e0147696 (2016).

Phaeton R, Jiang Z, Revskaya E, Fisher DR, Goldberg GL,  and  Dadachova E. Beta emitters Rhenium-188 and Lutetium-177 are equally effective in radioimmunotherapy of HPV-positive experimental cervical cancer. Cancer Med. 5(1):9-16 (2016).

McFarren A, Lopez L, Williams DW, Veenstra M, Bryan RA, Goldsmith A, Morgenstern A, Bruchertseifer F, Zolla-Pazner S, Gorny MK, Eugenin EA, Berman JW, Dadachova E. A fully human antibody to gp41 selectively eliminates HIV-infected cells that transmigrated across a model human blood brain barrier. AIDS 20;30(4):563-72 (2016).

Shuryak I. and Dadachova E.  New Approaches for Modeling Radiopharmaceutical Pharmacokinetics Using Continuous Distributions of Rates.  J. Nucl. Med.  56(10):1622-8 (2015).

M. Shah, G. Garg and E. Dadachova  Preclinical testing of radiopharmaceuticals for novel applications in HIV, bacterial  and fungal infectious diseases. Q. J. Nucl. Med. Mol. Imaging  59(3):317-26  (2015).

M. Shah,  R. Da Silva, C. Gravekamp,  S. K. Libutti, T. Abraham, E. Dadachova Targeted radionuclide therapies for pancreatic cancer. Cancer Gene Ther. 22:375–379 (2015).

Dadachova E. and  Berman JW.  Non-invasive nuclear imaging for localization of viral reservoirs. Nature Meth. 12(5):399-400 (2015).

Fahey F, Zukotynski K, Jadvar H, Capala J, Hill C, Köster U, Lewis J, Lin FI, Vikram B, Wahl R, Meredith RF, Cutler CS, Allen L, Satitpunwaycha R, O'Malley J, Baum R, Karzai F, Dadachova E, Reichert J, Brechbiel M, Wessels B, Larson S, Ahmed AK, Jacobs P, Goldenberg D, Schwarz S, Valliant J, Gillo J, Kluge A, Narayanan D, Evans G, Giaccone G, Pomper M, Lipkowitz S, Norenberg J, Malik S, Rohren EM. Proceedings of the Second NCI-SNMMI Workshop on Targeted Radionuclide Therapy.  J Nucl Med. 56(7):1119-29 (2015).

Prados-Rosales R, Toriola S, Nakouzi A, Chatterjee S, Stark R, Gerfen G, Tumpowsky P, Dadachova Е, Casadevall A. Structural characterization of melanin pigments from commercial preparations of the edible mushroom Auricularia auricula. J Agric Food Chem.  63(33):7326-32 (2015).

R. Phaeton, J. Gutierrez, Z. Jiang, R.G. Karabakhtsian, J. Albanese,  J. Sunkara,  D. R. Fisher, G.L. Goldberg, and E. Dadachova Naïve and radiolabeled antibodies to E6 and E7 HPV-16 oncoproteins show pronounced antitumor activity in experimental cervical cancer. Immunother. 7(6):631-40 (2015).

Rangel DE, Alder-Rangel A, Dadachova E, Finlay RD, Kupiec M, Dijksterhuis J, Braga GU, Corrochano LM, Hallsworth JE. Fungal stress biology: a preface to the Fungal Stress Responses special edition. Curr. Genet. 61(3):231-8 (2015).

Rangel DE, Alder-Rangel A, Dadachova E, Finlay RD, Dijksterhuis J, Braga GU, Corrochano LM, Hallsworth JE. The International Symposium on Fungal Stress: ISFUS. Curr Genet. 61(3):479-87 (2015).

Shuryak I, Bryan R, Broitman J, Marino S, Morgenstern A,  Apostolidis C, Dadachova  E. Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans. Nucl. Med. Biol. 42(6): 515-523 (2015).

C.S. Kang, Y. Chen, E. Dadachova, H.S. Chong Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides. J. Radioanal. Nucl. Chem. 303(3): 2407-2411 (2015).