Picture of Brian Bandy

Brian Bandy Associate Professor

Address
3D01.02 Health Sciences

Bio

Dr. Bandy joined the College in 2002, following positions as Research Associate and Postodoctoral Fellow at the University of Sao Paulo, Brazil. He is a member of the Canadian Society of Biochemistry and Molecular & Cell Biology, the Canadian Society for Nutritional Sciences and the Society for Free Radical Biology and Medicine.  He teaches undergraduate courses in Current Issues in Nutrition and Research Methods; contributes to senior Nutrition courses; coordinates and team teaches the graduate course Advances in Human Nutrition Research.

Research

Chief areas of interest are oxidative stress and apoptosis; free radical biochemistry and antioxidant interactions; mitochondrial biogenesis and respiratory activities.

Our research investigates the mechanisms of cellular oxidative stress, and the interactions of antioxidant and pro-oxidant polyphenols such as flavonoids and quinones. We focus on mitochondria, which in addition to generating reactive oxygen species as a byproduct of respiratory activity, are the organelles controlling programmed cell death (apoptosis). We are interested in factors that modulate mitochondrial oxidant generation and damage, with implications for aging and age-related illnesses such as cancer, neurodegenerative disorders, and heart disease.

Publications

  • Akhlaghi, M., Bandy, B. Protection by Plant Flavonoids Against Myocardial Ischemia-Reperfusion Injury (2013) Bioactive Food as Dietary Interventions for Cardiovascular Disease, pp. 415-429.
  • Helal, M., Das, U., Bandy, B., Islam, A., Nazarali, A.J., Dimmock, J.R. Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells (2013) Bioorganic and Medicinal Chemistry Letters, 23 (4), pp. 1075-1078.
  • Akhlaghi, M., Bandy, B. Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death (2012) Oxidative Medicine and Cellular Longevity, art. no. 782321.
  • Ling, B., Peng, F., Alcorn, J., Lohmann, K., Bandy, B., Zello, G.A. D-Lactate altered mitochondrial energy production in rat brain and heart but not liver (2012) Nutrition and Metabolism, 9, art. no. 6.
  • Das, S., Das, U., Bandy, B., Gorecki, D.K.J., Dimmock, J.R. 2-[4-(4 Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: A Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis (2010) Pharmazie, 65 (11), pp. 849-850.
  • Das, U., Das, S., Bandy, B., Gorecki, D.K.J., Dimmock, J.R. E-2-[3-(3,4-Dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1, 4-dioxide: A lead antitubercular agent which alters mitochondrial respiration in rat liver (2010) European Journal of Medicinal Chemistry, 45 (10), pp. 4682-4686.
  • Akhlaghi, M., Bandy, B. Dietary Broccoli Sprouts Protect Against Myocardial Oxidative Damage and Cell Death During Ischemia-Reperfusion (2010) Plant Foods for Human Nutrition, 65 (3), pp. 193-199.
  • Akhlaghi, M., Bandy, B. Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia-reperfusion (2010) Nutrition Research, 30 (1), pp. 32-39.