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Spotlight on Dr. Ekaterina Dadachova

Dr. Dadachova’s group is developing novel radioimmunotherapy-based approaches for the treatment of cancer and infectious diseases.

Bio

Dr. Ekaterina Dadachova holds the Silvia Fedoruk Center for Nuclear Innovation Chair in Radiopharmacy. She received her Bachelor in Chemistry and PhD in Physical Chemistry degrees from Moscow State University, Russia. She did her postdoctoral studies in radiopharmaceutical chemistry at the Australian Nuclear Science and Technology Organization and was a visiting associate at the U.S. National Institutes of Health. Prior to joining the College of Pharmacy and Nutrition, she held a professorship in Radiology, Microbiology and Immunology at the Albert Einstein College of Medicine in New York.

Research Programs

Dr. Dadachova’s research group has pioneered radioimmunotherapy of infections including fungal and bacterial infections and HIV. Her other research interests include radioimmunotherapy of melanoma, pancreatic cancer, and osteosarcoma as well the development of melanin-based radioprotectors. She is currently funded by SHRF, Canadian Space Agency, Wendy Walk Foundation, Burroughs Wellcome Fund, and private industry.

Recent Publications

Pacelli C, Bryan RA, Onofri S, Selbmann L, Zucconi L, Shuryak I, Dadachova E. Survival and redox activity of Friedmanniomyces endolithicus, an Antarctic endemic black meristematic fungus, after gamma rays exposure. Fungal Biol. 2018 Dec;122(12):1222-1227.

Helal M, Dadachova E. Radioimmunotherapy as a Novel Approach in HIV, Bacterial, and Fungal Infectious Diseases. Cancer Biother Radiopharm. 2018 Oct;33(8):330-335.

Pacelli C, Selbmann L, Zucconi L, Coleine C, de Vera JP, Rabbow E, Böttger U,  Dadachova E, Onofri S. Responses of the Black Fungus Cryomyces antarcticus to Simulated Mars and Space Conditions on Rock Analogues. Astrobiology. 2018 Aug 1.

Allen KJH, Jiao R, Malo ME, Dadachova E. Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of Humanized Antibodies with (188)Rhenium. Cancer Biother Radiopharm. 2018 Oct;33(8):349-355.

Rangel DEN, Finlay RD, Hallsworth JE, Dadachova E, Gadd GM. Fungal strategies for dealing with environment- and agriculture-induced stresses. Fungal Biol. 2018 Jun;122(6):602-612.

Selbmann L, Pacelli C, Zucconi L, Dadachova E, Moeller R, de Vera JP, Onofri S. Resistance of an Antarctic cryptoendolithic black fungus to radiation gives new insights of astrobiological relevance. Fungal Biol. 2018 Jun;122(6):546-554.

Malo ME, Bryan RA, Shuryak I, Dadachova E. Morphological changes in melanized and non-melanized Cryptococcus neoformans cells post exposure to sparsely and densely ionizing radiation demonstrate protective effect of melanin. Fungal Biol. 2018 Jun;122(6):449-456.

Jiang Z, Revskaya E, Fisher DR, Dadachova E. In vivo Evaluation of Free and Chelated Accelerator-produced Actinium- 225 - Radiation Dosimetry and Toxicity Results. Curr Radiopharm. 2018;11(3):215-222.

Pacelli C, Bryan RA, Onofri S, Selbmann L, Zucconi L, Shuryak I, Dadachova E. The effect of protracted X-ray exposure on cell survival and metabolic activity of fast and slow growing fungi capable of melanogenesis. Environ Microbiol Rep. 2018 Jun;10(3):255-263.

 

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