Dr. Paterson joined the faculty in 1989 following a postdoctoral fellowship at the Hospital for Sick Children Research Institute in Toronto. She is a Principal Investigator at the CAMECO MS Neuroscience Research Center and a Member of the Neuroscience Research Cluster at the University of Saskatchewan.
Stroke, a reduction in blood flow to a region of the brain, is a major cause of disability. Novel treatment strategies are urgently needed, and the potential influence of nutritional status is often neglected. Thus, my laboratory is studying the effects of clinically relevant nutritional states on the extent of brain damage and disability caused by a stroke and the underlying mechanisms. Our most recent research interests are to investigate how nutrition can enhance recovery mechanisms and rehabilitation strategies after stroke. As part of the Canadian Institutes of Health Research/Heart and Stroke Foundation of Canada Team in Synchrotron Medical Imaging, I am also developing synchrotron-based imaging of brain biochemistry that is linked to recovery of function following stroke.
Undergraduate course in Clinical Nutrition; team teaches the graduate course Advances in Human Nutritional Sciences Research.
M. Alaverdashvili, M.J. Hackett, I.J. Pickering and P.G. Paterson, 2014. Laminar-specific distribution of zinc: Evidence for presence of layer IV in forelimb motor cortex in the rat. Neuroimage Sep 2. pii: S1053-8119(14)00720-4. doi: 10.1016/j.neuroimage.2014.08.046. [Epub ahead of print].
S.E. Smith, S.A. Figley, D.J. Schreyer and P.G. Paterson, 2014. Protein-energy malnutrition developing after global brain ischemia induces an atypical acute-phase response and hinders expression of GAP-43. PLoS One, Sep 26;9(9):e107570.
M. Alaverdashvili, X. Li, P.G. Paterson, 2014. Adulthood protein-energy malnutrition affects post-stroke skilled movements in rats. Advances in Stroke Recovery, Heart and Stroke Foundation, Canadian Partnership for Stroke Recovery, Ottawa, ON, June 9-10 (poster).
S.E. Smith, R. Andrade Ramos, R. Refinetti, J.P. Farthing and P.G. Paterson, 2013. Protein-energy malnutrition induces an aberrant acute-phase response and modifies the circadian rhythm of core temperature. Applied Physiology, Nutrition and Metabolism 38: 844-853.
M.J. Hackett, F. Borondics F, D. Brown, C. Hirschmugl, S.E. Smith, P.G. Paterson, H. Nichol, I.J. Pickering, and G.N. George, 2013. Subcellular biochemical investigation of Purkinje neurons using synchrotron radiation Fourier transform infrared spectroscopic imaging with a focal plane array detector, ACS Chemical Neuroscience 4: 1071-1080.
M.J. Hackett, S.E. Smith, P.G. Paterson, H. Nichol, I.J. Pickering and G.N. George, 2012. X-ray absorption spectroscopy at the sulfur K-edge: A new tool to investigate the biochemical mechanisms of neurodegeneration. ACS Chemical Neuroscience 3: 178-185.
M.D. Dubyk, R.T. Card, S.J. Whiting, C.A.J. Boyle, S.H. Zlotkin and P.G. Paterson, 2012. Iron deficiency anemia prevalence at first stroke or transient ischemic attack. Canadian Journal of Neurological Sciences 39: 189-195.
A.M. Auriat, G. Silasi, Z. Wei, R. Paquette, P. Paterson, H. Nichol, and F. Colbourne, 2012. Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome, Experimental Neurology 234: 136-143.