Research Output

In the past three years (2021-2023), our hub have trained 41 High Quality Personnel, including 15 Ph.D., 6 M.Sc., 8 undergraduate students, 2 postdoctoral fellows, 6 technical staff, 2 visiting Ph.D. students, and 2 research scientists.

Publications (2021-2023):

Khajavinia A, Michel D, Ezeaka UC, Purves RW, Laprairie RB and El-Aneed A (2024). Addressing a Major Interference in the Quantification of Psilocin in Mouse Plasma: Development of a Validated Liquid Chromatography Tandem Mass Spectrometry Method. Journal of Chromatography A, Volume 1730, 465123.

Black, T., Baccetto, S.L., Barnard, I.L., Finch, E., McElroy, D.L., Austin-Scott, F.V.L., Greba, Q., Michel, D., Zagzoog, A., Howland, J.G., & Laprairie, R.B. (2023). Characterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure. Scientific Reports. 13(1): 21070.

Barnard, I.L., Onofrychuk, T.J., Toderash, A.D., Patel, V.N., Glass, A.E., Adrian, J.C., Laprairie, R.B., & Howland, J.G. (2023). High-THC Cannabis smoke impairs working memory capacity in spontaneous tests of novelty preference for objects and odors in rats. eNeuro. doi: 10.1523/ENEURO.0115-23.2023

Sandini, T.M., Onofrychuk, T.J., Roebuck, A.J., Hammond, A., Udenze, D., Hayat, S., Herdzik, M.A., McElroy, D.M., Orvold, S.N., Greba, Q., Laprairie, R.B., and Howland, J.G. (2023). Repeated exposure to high-THC Cannabis smoke during gestation alters sex ratio, behavior, and amygdala gene expression of Sprague Dawley rat offspring. eNeuro. doi: 10.1523/ENEURO.0100-23.2023.

Gabriel Bernardes, Ed S. Krol, (2023). In vitro hepatic metabolism of the natural product quebecol. Xenobiotica, 53 (1), 1-11. doi:10.1080/00498254.2023.2180691

Gabriel Bernardes, Omer Munir, Ed S. Krol, 2023. The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of a-synuclein in vitro. Bioorganic and Medicinal Chemistry, 78, 116147. doi: 10.1016/j.bmc.2022.117147

JK Haile, D Sertse, A N’Diaye, V Klymiuk, et al. (2023) Multilocus genome-wide association studies reveal the genetic architecture of Fusarium head blight resistance in durum wheat. Front. Plant Sci. 14: 1182548. doi: 10.3389/fpls.2023.1182548

Poudel A, Gachumi G, Paterson PG, El-Aneed A, Badea I. (2023) Liposomal phytosterols as LDL-cholesterol lowering agents in diet-induced hyperlipidemia. Molecular Pharmaceutics, 20, 4443–4452

Elessawy F, Hughes J, Khazaei H, Vandenberg A, El-Aneed, A, Purves R. (2023). A comparative metabolomics investigation of flavonoid variation in faba bean flowers. Metabolomics,  19, 52.

Elessawy F, Wright D, Vandenberg A, El-Aneed, A, Purves R. (2023). Mass spectrometry-based untargeted metabolomics reveals the importance of glycosylated flavones in lentil seed coat patterns. Journal of Agricultural and Food Chemistry, 2023, 71 (7) 3541–3549

Khajavinia A and El-Aneed A. (2023). Carbon-based nanoparticles and their surface-modified counterparts as MALDI matrices.  Analytical Chemistry, 95 (1), 100-114.

Khajavinia A, Yarahmadi M, El-Aneed A, Haddadi A. Development of a liquid chromatography-tandem mass spectrometry method for the analysis of docetaxel-loaded Poly (lactic-co-glycolic acid) nanoparticles. Journal of Pharmaceutical and Biomedical Analysis. (2023). Volume 223, 20 January, 115114. doi: 10.1016/j.jpba.2022.115114

Barnard, I.L., Onofrychuk, T.J., Sandini, T.M., McElroy, D.L., Zagzoog, A., Roebuck, A.J., Austin-Scott, F.V., Laprairie, R.B., and Howland, J.G. (2022). The effects of acute Cannabis smoke or Δ 9-THC injections on the trial-unique, nonmatching-to-location and five-choice serial reaction time tasks in male Long-Evans rats. Neurobiology of Learning and Memory, 192(1): 107624.

Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J.H. Allen, Jeremy S. Lee, Christopher P. Phenix and Ed S. Krol, (2022). An HPLC-UV validated bioanalytical method for measurement of in vitro Phase 1 kinetics of α-synuclein binding bifunctional compounds. Xenobiotica, 52 (8), 916-927. doi: 10.1080/00498254.2022.2140315

Wang L, Michel D, Zhang W, El-Aneed A, Fobert PR, Ruan Y, Berraiers S, Cuthbert R, Kutcher HR. A high-throughput fast chromatography tandem mass spectrometry (FC-MS/MS) based method for deoxynivalenol (DON) quantification in wheat grain. (2022). PhytoFrontiers. https://doi.org/10.1094/PHYTOFR-03-22-0024-TA

Poudel A, Gachumi G, Purves R, Badea I, El-Aneed A. (2022) Determination of phytosterol oxidation products in pharmaceutical liposomal formulations and plant vegetable oil extracts using novel fast liquid chromatography - Tandem mass spectrometric methods. Analytica Chimica Acta. Feb 15;1194:339404. doi: 10.1016/j.aca.2021.339404

Mansell H, Quinn D, Kelly LE, Alcorn J (2022). Cannabis for the treatment of attention deficit hyperactivity disorder: a report of three cases. Medical Cannabis and Cannabinoids. 5:1–6. doi.org/10.1159/000521370

Roebuck, A.J., Greba, Q., Onofrychuk, T.J., McElroy, D.L., Sandini, T.M., Zagzoog, A., Simone, J., Cain, S.M., Snutch, T.P., Laprairie, R.B., & Howland, J.G. (2021). Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg. European Journal of Neuroscience, 55(4): 1063-1078.

Chukwunonso K. Nwabufo, Omozojie P. Aigbogun, Kevin J.H. Allen, Madeline N. Owens, Jeremy S. Lee, Christopher P. Phenix and Ed S. Krol, (2021). Employing in vitro Metabolism to Guide Design of F-Labelled PET Probes of Novel -Synuclein Binding Bifunctional Compounds. Xenobiotica, 50 (8), 885-900. doi:10.1080/00498254.2021.1943566

G Singh, G Hnatowich, G Peng, and HR Kutcher, (2021). Fungicide mitigates Fusarium head blight in durum wheat when applied as late as the end of flowering in western Canada. Plant Disease 105: 11, 3481-3489.

Elessawy F, Vandenberg A, El-Aneed A, Purves RW. (2021)  An untargeted metabolomics approach for correlating pulse crop seed coat polyphenol profiles with antioxidant capacity and iron chelation ability. Molecules, 26, 3833. DOI 10.3390/molecules26133833

Khajavinia A, Haddadi A, El-Aneed A. (2021). Establishment of the tandem mass spectrometric fingerprints of taxane-based anticancer compounds. Rapid Communications in Mass Spectrometry, 35:e9107. doi: 10.1002/rcm.910 

Gachumi G, Demelenne A, Poudel A, Dallal Bashi Z, El-Aneed A. (2021). Novel fast chromatography-tandem mass spectrometric quantitative approach for the determination of plant-extracted phytosterols and tocopherols. Molecules. 26, 1402. DOI 10.3390/molecules26051402

Gachumi G, Poudel A, Wasan K, El-Aneed A. (2021). Analytical strategies to analyze the oxidation products of phytosterols, and formulation-based approaches to reduce their generation. Pharmaceutics, 2021, 13, 268.DOI 10.3390/pharmaceutics13020268.

Guo Y, Yang X, Tse T, Purdy SK, Mustafa R, Shen J, Alcorn J, Reaney MJT, (2021). Hypocholesterolemic efficacy of SDG and SDG polymer in rat. Journal of Natural Products. 84(11):2845-2850. doi: 10.1021/acs.jnatprod.1c00549

Mansell H, Quinn D, Alcorn J (2021) Pharmacokinetics and perceptions of children and young adults using Cannabis for ADHD and ODD: A Mixed-Methods Proof-of-Concept Study". JMIR Research Protocols. 2021 Oct 18;10(10):e31281. doi: 10.2196/31281

Yang X, Guo Y, Tse T, Purdy SK, Mustafa R, Shen J, Alcorn J, Reaney MJT (2021). Oral pharmacokinetics of purified SDG and SDG polymer in rat. Journal of Natural Products, 84(6):1816-1822. doi: 10.1021/acs.jnatprod.1c00335