Dr. Ed Krol is associate professor of Pharmacy and division graduate chair. He graduated with a BSc in Chemistry (McMaster) and worked in the Dept. of Chemical Engineering at the Royal Military College in Kingston, Ontario. He then completed a PhD in Physical Organic Chemistry (Queen’s) and held postdoctoral positions at the University of Illinois-Chicago and University of Arizona. He was a faculty member in the Dept. of Chemistry at Brandon University before coming to the University of Saskatchewan in 2001.
Dr. Krol teaches medicinal chemistry and drug metabolism in the Pharmacy undergraduate and graduate programs and also teaches in the Dept. of Chemistry.
In 2008, Dr. Krol established the Western Canadian Medicinal Chemistry Workshop. A biennial event, the WCMCW provides a forum for researchers and trainees in the pharmaceutical sciences to connect and share their work.
ResearchDr. Krol’s research program focuses on natural products with potential health benefits. Specifically, the metabolism of flaxseed lignans; the therapeutic properties of lignan analogues; and the development of 18F lignan probes for positron emission tomography. He is also studying the photoprotective properties of naturally-occurring flavonols and stability issues with natural products. Recently, his group has begun to develop probes for inhibiting alpha-synuclein misfolding to better understand Parkinson’s disease. Students from his research group have gone on to faculty positions and work in government and pharmaceutical labs.
- Jatinder Kaur Mukker, Deborah Michel, Alister D. Muir, Ed S. Krol and Jane Alcorn, 2014. Permeability and Conjugative Metabolism of Flaxseed Lignans by Caco-2 Human Intestinal Cells. Journal of Natural Products, 77(1) 29-34.
- Chaojie Lin, Ed S Krol and Jane Alcorn, 2013. The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans. The Natural Products Journal, 3 (3) 159-171.
- Natasha Vetter, David Langill, Shazia Anjum, Julie Boisvert, Rajendra Jagdhane, Egiroh Omene, Hongyan Zheng, Karin van Straaten, , Isaac Asiamah, Ed S. Krol, David Sanders, David Palmer, 2013. A Previously-Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis. Journal of the American Chemical Society, 135(16), 5970-5973.
- Sabia Maini, Heather L. Hodgson and Ed S. Krol, 2012. The UVA and aqueous stability of flavonoids is dependent on B-ring substitution. Journal of Agricultural and Food Chemistry. 60(28), 6966-6976.
- Ed S. Krol and Lisa M. Krol, 2012. Referencing and Citation for Graduate Students: Gain Without Pain. Collected Essays on Learning and Teaching. 5, 65-68.