Picture of Hector  Caruncho

Hector Caruncho Adjunct Professor

Address
Division of Medical Sciences, University of Victoria

Bio

My professional activities at the University of Saskatchewan include building academic and research bridges between the College of Pharmacy and Nutrition and the College of Medicine, as well as to develop collaborations with scientists at the UofS (and other national and international institutions) devoted to the discovery of novel biomarkers and novel drug targets of mental disorders.

Research

I started my research in the field of fish neurobiology, and later became interested in studying the stoichiometry of GABAA receptors and the alteration in GABAA receptor subunits during processes of tolerance to benzodiazepine treatment. I also studied alterations in GABAergic systems in animal models of Parkinson’s disease and Huntington’s disease. Thereafter, in collaboration with Dr. Erminio Costa (University of Illinois at Chicago) I studied reelin deficits in schizophrenia and the epigenetic mechanisms related to those deficits. Lately, in collaboration with Dr. Lisa Kalynchuk (University of Saskatchewan) I am studying the neurobiology of animal models of depression. A few years ago, I started a new research line devoted to the discovery of novel biomarkers of mental disorders.

 

Publications

Google Scholar Profile

  • Botterill, J.J., Guskjolen, A.J., Marks, W.N., Caruncho, H.J., Kalynchuk, L.E. Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor (2015) Brain Structure and Function, 220 (6), pp. 3641-3655.
  • Fenton, E.Y., Fournier, N.M., Lussier, A.L., Romay-Tallon, R., Caruncho, H.J., Kalynchuk, L.E. Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation (2015) Progress in Neuro-Psychopharmacology and Biological Psychiatry, 60, pp. 52-59.
  • Varela, M.J., Lage, S., Caruncho, H.J., Cadavid, M.I., Loza, M.I., Brea, J. Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study (2015) Neuroscience, 290, pp. 165-174.
  • Perez-Costas, E., Fenton, E.Y., Caruncho, H.J. Reelin expression in brain endothelial cells: An electron microscopy study (2015) BMC Neuroscience, 16 (1), art. no. 16. Link Highly Accessed
  • Romay-Tallon, R., Rivera-Baltanas, T., Kalynchuk, L.E., Caruncho, H.J. Differential effects of corticosterone on the colocalization of reelin and neuronal nitric oxide synthase in the adult hippocampus in wild type and heterozygous reeler mice (2015) Brain Research, 1594, pp. 274-283.
  • Botterill, J.J., Brymer, K.J., Caruncho, H.J., Kalynchuk, L.E. Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory (2015) Epilepsy and Behavior, 47, pp. 83-92.
  • Botterill, J.J., Guskjolen, A.J., Marks, W.N., Caruncho, H.J., Kalynchuk, L.E. Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor (2014) Brain Structure and Function
  • Rivera-Baltanas T, Olivares JM, Calado M, Kalynchuk LE, Caruncho HJ (2013) 5- HT2A receptor clustering in lymphocytes in major depression: Relevance as a putative biomarker of therapeutic efficacy. Journal of Affective Disorders.
  • Lussier AL, Lebedeva K, Sterner EY, Guskjolen A, Caruncho HJ, Kalynchuk LE (2013) The progressive development of depression-like behavior in corticosterone-treated rats  is paralleled by slowed granule cell maturation and decreased reelin expression in the subgranular zone of the dentate gyrus. Neuropharmacology, 71:174-83.
  • Lussier AL, Romay-Tallon R, Caruncho HJ, Kalynchuk LE (2013) Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress, Neuroscience, 231:38-48.
  • Rivera-Baltanas T, Olivares JM, Calado M, Villamarin JR, Kalynchuk LE, Caruncho HJ (2012) Serotonin transporter (SERT) clustering in blood lymphocytes as a putative biomarker of therapeutic efficacy in major depressive disorder. Journal of Affective Disorders, 137:46-55.
  • Botterill JJ, Guskjolen AJ, Kalynchuk LE, Caruncho HJ (2012) Rodent models as tools to discover novel therapeutic targets in the brain: The case of epilepsy. In “Therapeutic targets: modulation, inhibition, and activation”. M.I. Loza & L. Botana (eds). John Wiley  & Sons. Hoboken NJ. ISBN: 9780470587195, pp: 427-454.
  • Sterner E, Kalynchuk LE, Caruncho HJ (2012) Targeting brain epigenetic abnormalities. In “Therapeutic targets: modulation, inhibition, and activation”. M.I. Loza & L. Botana (eds). John Wiley & Sons. Hoboken NJ. ISBN: 9780470587195, pp: 409-426.