Dr. Nazarali joined the faculty in July 1995. He has worked with Nobel Laureate, Dr. Marshall Nirenberg, at the National Institutes of Health in the United States in the cloning of murine Hox genes.
Dr. Nazarali’s areas of teaching include Developmental Biology, Pharmaceutical Biotechnology and Toxicology.
Molecular biology; cell biology; pharmaceutical biotechnology; drug metabolism.
The research focus of the Laboratory of Molecular Biology, College of Pharmacy and Nutrition is the molecular cloning and expression analysis of homeobox (Hox) genes in the developing mammalian embryo including the eye, palate and myelinating glia. Methodologies for isolation of downstream targets of homeobox genes are being developed. The mechanism of anticonvulsant drug-induced teratogenicity is also being investigated.
Dr. Nazarali’s research has been funded by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC) and the Multiple Sclerosis Society of Canada. Recent studies have focused on molecular cloning and expression analysis of homeobox genes in the developing mammalian embryo, and isolation of downstream targets of homeobox genes.
Smith, T.M., Lozanoff, S., Iyyanar, P.P., Nazarali, A.J. Molecular signaling along the anterior-posterior axis of early palate development (2013) Frontiers in Physiology, 3 JAN, art. no. Article 488.
Helal, M., Das, U., Bandy, B., Islam, A., Nazarali, A.J., Dimmock, J.R. Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells (2013) Bioorganic and Medicinal Chemistry Letters, 23 (4), pp. 1075-1078.
Wei, Z., Gabriel, G.G., Rui, L., Cao, X., Pennington, P.R., Chlan-Fourney, J., Nazarali, A.J., Baker, G.B., Mousseau, D.D. Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex (2012) Journal of Alzheimer's Disease, 28 (2), pp. 403-422.
Ji, S., Doucette, J.R., Nazarali, A.J. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation (2011) Journal of Molecular Cell Biology, 3 (6), pp. 351-359.
Wang, Y., Zhang, Y., He, J., Zhang, H., Xiao, L., Nazarali, A., Zhang, Z., Zhang, D., Tan, Q., Kong, J., Li, X.-M. Hyperforin promotes mitochondrial function and development of oligodendrocytes (2011) Journal of Neurochemistry, 119 (3), pp. 555-568.
Nazarali, A.J. Marshall Nirenberg 1927-2010. (2011) Cellular and molecular neurobiology, 31 (6), pp. 805-807.
Wang, M., Doucette, J.R., Nazarali, A.J. Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein. (2011) Cellular and molecular neurobiology, 31 (6), pp. 875-886.
Elsabahy, M., Nazarali, A., Foldvari, M. Non-viral nucleic acid delivery: Key challenges and future directions (2011) Current Drug Delivery, 8 (3), pp. 235-244.
Wang, M., Doucette, J.R., Nazarali, A.J. Conditional Tet-Regulated Over-Expression of Hoxa2 in CG4 Cells Increases Their Proliferation and Delays Their Differentiation into Oligodendrocyte-like Cells Expressing Myelin Basic Protein (2011) Cellular and Molecular Neurobiology, pp. 1-12.
Brown, GD and Nazarali, AJ, 2010. Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-b3. BMC Developmental Biology.10:93-102.
J. R. Doucette, R. Jiao, A. J. Nazarali, 2010 Age-related and cuprizone-induced changes in myelin and transcription factor gene expression and in oligodendrocyte cell densities in the rostral corpus callosum of mice. Cellular and Molecular Neurobiology,30:607-629.
Zhang B, Wang X, Nazarali AJ, 2010. Ascorbic acid reverses valproic acid induced inhibition of Hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cellular and Molecular Neurobiology, 30:137–148.
T.M. Smith, X. Wang, B. Zhang W, Kulyk, AJ Nazarali, 2009. Hoxa2 plays a direct role in murine palate development. Developmental Dynamics, 238: 2364-2373.
L. Ji, A.J. Nazarali and P.G. Paterson, 2008. Protein-Energy Malnutrition Increases Activation of Transcription Factor, Nuclear Factor Kappa B, in Gerbil Hippocampus Following Global Ischemia, Journal of Nutritional Biochemistry, 19, 770-777.
D.J. Nicolay, J.R. Doucette and A.J. Nazarali, 2007. Transcriptional Control of Oligodendrogenesis, GLIA, 55, 1287-1299.
J. Booth, D.J. Nicolay, J.R. Doucette and A.J. Nazarali, 2007. Hoxd1 is Expressed by Oligondendroglial Cells and Binds to a Region of the Human Myelin Oligodendrocyte Glycoprotein Promoter In Vitro, Cellular and Molecular Neurobiology, 27, 641-650.